Hen'
Conditions
Interventions
Bifidobacteria, twice a day, 42 weeks
Dextrin, twice a day, 42 weeks
Sponsors
Showa University, Department of pediatrics
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: a) Obvious hen's egg allergic patients b) Patients who are 2 years or older and 5 years or younger at the start of the study c) After receiving sufficient explanation for the participation of this study, patients who obtained document consent with the free will of the patient himself or substitute person with sufficient understanding
Exclusion criteria
Exclusion criteria: a) Of control poor atopic dermatitis or bronchial asthma b) Cardiovascular, cranial nerve, Renal urology, Hepatobiliary, pancreatic, gastrointestinal, etc, which are serious or have diseases which may affect research c) Implementing other immunotherapy d) Other test responsibilities(shared) patients judged inappropriate by the doctor as subjects
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rate of 1/8 hen's egg tolerance at 32 weeks after intervention started | — |
Secondary
| Measure | Time frame |
|---|---|
| The rate of 1/32 hen's egg desensitization at 32 weeks after intervention started. Objective indicater(blood:change in eosinophil count,total IgE,antien specific IgE(egg white,egg yolk,ovomucoid),antigen specific IgG4(egg white,ovomucoid),basophil stimulation test(OVM), faeces:intestinal flora, calprotectin,skin prick test) Side reaction rate on oral immunotherapy, Safety assessment(incidence of adverse events) | — |
Countries
Japan
Contacts
Public ContactMayu Maeda
Showa University Department of Pediatrics
Outcome results
None listed