Bipolar disorder and major depressive disorder
Conditions
Interventions
Reminders of blood test of serum lithium levels per every 6 months
Standard care
Sponsors
Graduate School of Medicine and Public Health, Kyoto University
Toyooka Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Bipolar disorder or major depressive disorder according to DSM-5 2) Taking lithium carbonate longer than six months 3) Need to continue lithium carbonate over 18 months (as judged by treating psychiatrist)
Exclusion criteria
Exclusion criteria: 1) Prescribed lithium for a condition other than mood disorder 2) Who did not provide written informed consent 3) Schizophrenia 4) Inappropriate/unable to participate in the trial (as judged by treating psychiatrist) 5) Serious suicide intent (as judged by treating psychiatrist) 6) Lithium intoxication 7) Pregnancy 8) Researcher of the trial and their family 9) Who cannot read Japanese 10) Contraindication of lithium 11) Participation in another clinical trial 12) Inpatients 13) End-stage physical disease 14) Who did not have serum lithium level measurement at baseline 15) Who did not visit hospital between 4-8 months after inclusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The proportion of patients with serum lithium level between 0.4 and 1.0 mEq/l between 18 and 24 months after inclusion | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Number of tests of serum lithium level within 18-24 months after inclusion 2) Exacerbation of mood disorder including admission, a dose increase of lithium, an addition of antipsychotics, antidepressants or mood stabilizers 3) The proportion of days when lithium was prescribed during the study period | — |
Countries
Japan
Contacts
Public ContactTomotsugu Seki
Graduate School of Medical Science, Kyoto Prefectural University of Medicine Department of Cardiovascular Medicine
Outcome results
None listed