Hypophosphatasia
Conditions
Interventions
None listed
Sponsors
Osaka University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Healthy subjects should meet the criteria 1 and 3, and HPP patients should meet the criteria 2 to 3. 1.Healthy children aged 2 years or older and 16 years or younger who can visit dentists and for whom panoramic photographs are applicable 2.Patients diagnosed as HPP aged 2 years or older and 16 years or younger who can visit dentists and for whom panoramic photographs need can to be taken 3.Informed consent can be obtained in writing from the study subjects/patients themselves or their legally authorized representatives
Exclusion criteria
Exclusion criteria: Healthy subjects who fall under any of the following criteria 1 to 4, and pediatric HPP patients who fall under the criteria 3 or 4 will be excluded from enrollment in this study. 1.Those with severe dental caries, periodontal disease, etc. 2.Patients with skeletal dysplasia other than HPP 3.Those who have received dental treatment potentially affecting radiography 4.Those who are regarded as ineligible for enrollment in this study by the investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The data on the following items from healthy subjects and HPP patients will be collected from the panoramic radiographic images obtained using the indicator. Bone density of alveolar bone The degree of alveolar crest resorption (CEJ-ABC distance) Dental ages estimated by Haavikko's method | — |
Secondary
| Measure | Time frame |
|---|---|
| Dental information of healthy subjects, and the data on dental manifestations in HPP patients irrespective of the presence or absence of therapeutic intervention (e.g., dosing of Asfotase alfa and/or dental care (tooth filling, dental pulp treatment, crown restoration, tooth extraction, denture, periodontal treatment etc.)) will be collected. The data on the following items will be collected from the questionnaire survey and the panoramic radiographic images obtained using the indicator. Items collected from a medical chart review used to complete a questionnaire; Age Gender Age at the time of radiography Dental formula Dental complications (dentinogenesis imperfecta, amelogenesis imperfecta, gingivitis, periodontal disease, dental caries (including DMF index), morphological abnormality, etc.) Dental treatment (treat or not, as well as treatment method and timing) The following information will also be collected for HPP patients from a medical chart review used to complete a questionnaire. Clinical types of HPP perinatal-, infantile-, childhood- or odontotypes) Results of ALPL gene mutation analysis Age at diagnosis of HPP Exfoliation of premature teeth and permanent teeth at each position (number and age at exfoliation) Depth of the periodontal pockets and the presence or absence of bleeding (premature teeth: 1 point method; permanent teeth: 6 points method) Tooth mobility of premature teeth and permanent teeth (Grade 0,1, 2, 3) Dental age | — |
Countries
Japan
Contacts
Public ContactRena Okawa
Osaka University Dental Hospital Dept. of Pediatric Dentistry
Outcome results
None listed