pulmonary Mycobacterium avian complex infection
Conditions
Interventions
JINSHIHOUTOU 9.0g/d (3M~2Y)
Sponsors
Faculty of Medical Sciences University of Fukui
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.age between 20 and under 80 2.Gender: male and female 3.Outpatient only 4.Patients satisfying the diagnostic criteria for pulmonary MAC disease) A.Clinical criteria (satisfy the following two) 1.Chest CT findings indicate nodular shadow or branched shadow, cavitary shadow, bronchiectasis findings. 2.Can exclude other diseases B.Bacteriological criteria (satisfies one) 1.Culture positive with two or more different sputum 2.Positive cultures in one or more bronchial lavage fluids 3.For transbronchial lung biopsy or lung biopsy tissue, histology findings conformed with pulmonary MAC disease and at the same time tissue or bronchial lavage fluid or sputum one or more culture positive The above A and B are satisfied. 5. Rifampicin, ethambutol, clarithromycin, streptomycin, kanamycin, rifabutin, sitafloxacin, levofloxacin were not administered more than 14 days. 6. Patients who got informed consent.
Exclusion criteria
Exclusion criteria: 1.Rifampicin, ethambutol, clarithromycin, streptomycin, kanamycin, rifabutin, sitafloxacin, levofloxacin are administered 2.Treated for pulmonary tuberculosis 3.With hypokalemia 4.With heart failure 5.With drug hypersensitivity 6.Pregnant and lactating women 7.Patients who participated in other clinical trials within 4 months 8.In addition, patients who are judged inappropriate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CAT score, body weight and NK cell activity on administration and 3 months later. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of exacerbation factors for exacerbation group and non-exacerbation group Depression score by SDS, STAI Chest CT findings Evaluation of exacerbation factors for exacerbation group and non-exacerbation group evaluation of safety | — |
Countries
Japan
Contacts
Public ContactYuko Waseda
Faculty of Medical Sciences University of Fukui Third Department of Internal Medicine
Outcome results
None listed