The study for predictive markers of vessel invasion of gastric cancer

The study for predictive markers of vessel invasion of gastric cancer - The study for predictive markers of vessel invasion of gastric cancer

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000033554

Enrollment

153

Registered

2018-08-01

Start date

2018-05-29

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastric cancer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients who are 20 years of age or older at the time of obtaining informed consent 2. Patients who are diagnosed as gastric cancer by biopsy 3. Patients who are resected stomach as treatment for gastric cancer 4. Patients who are informed and have provided written informed consent to participate in the study prior to study initiation

Exclusion criteria

Exclusion criteria: 1. Patients by whom principal investigator has determined to be inappropriate as a subject

Design outcomes

Primary

Measure	Time frame
Discrimination ability of vessel invasion by immunohistochemical staining of beta-catenin, E-cadherin, sox10 and EGFR 1. The relevance between the membrane positive rate of beta-catenin and the degree of vessel invasion 2. The relevance between the membrane positive rate of E-cadherin and the degree of vessel invasion 3. The relevance between the positive rate of sox10 and the degree of vessel invasion 4. The relevance between the positive rate of EGFR and the degree of vessel invasion	—

Measure

Time frame

Discrimination ability of vessel invasion by immunohistochemical staining of beta-catenin, E-cadherin, sox10 and EGFR 1. The relevance between the membrane positive rate of beta-catenin and the degree of vessel invasion 2. The relevance between the membrane positive rate of E-cadherin and the degree of vessel invasion 3. The relevance between the positive rate of sox10 and the degree of vessel invasion 4. The relevance between the positive rate of EGFR and the degree of vessel invasion

—

Secondary

Measure	Time frame
1. The concordance rate of histology of biopsy specimen and resection specimen 2. The concordance rate of immunohistochemistry of biopsy specimen and resection specimen 3. The relevance between vessel invasion and histology 4. The relevance between vessel invasion and infiltration type 5. The relevance between vessel invasion and progression free survival 6. The relevance between vessel invasion and overall survival 7. The relevance between the result of immunohistochemical staining of each molecule and histology 8. The relevance between the result of immunohistochemical staining of each molecule and infiltration type 9. The relevance between the result of immunohistochemical staining of each molecule and progression free survival 10. The relevance between the result of immunohistochemical staining of each molecule and overall survival	—

Measure

Time frame

1. The concordance rate of histology of biopsy specimen and resection specimen 2. The concordance rate of immunohistochemistry of biopsy specimen and resection specimen 3. The relevance between vessel invasion and histology 4. The relevance between vessel invasion and infiltration type 5. The relevance between vessel invasion and progression free survival 6. The relevance between vessel invasion and overall survival 7. The relevance between the result of immunohistochemical staining of each molecule and histology 8. The relevance between the result of immunohistochemical staining of each molecule and infiltration type 9. The relevance between the result of immunohistochemical staining of each molecule and progression free survival 10. The relevance between the result of immunohistochemical staining of each molecule and overall survival

—

Countries

Japan

Contacts

Public ContactMarin Ishikawa

Hokkaido University Hospital Division of Endoscopy

marin.0719@med.hokudai.ac.jp+81-11-716-1161

Outcome results