PAIN control after laparoscopic Surgery using EpiduRal anesthesia Versus Intravenous aCEtaminophen with local anesthesia: an open-label pilot study

PAIN control after laparoscopic Surgery using EpiduRal anesthesia Versus Intravenous aCEtaminophen with local anesthesia: an open-label pilot study - l-PAIN SERVICE pilot trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000033472

Enrollment

Registered

2018-08-01

Start date

2018-10-22

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing laparoscopic surgery

Interventions

Acelio Intravenous Injection 1000mg with local anesthesia Epidural anesthesia with local anesthesia local anesthesia

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)Patients undergoing laparoscopic surgery including robotic surgery i)gastrectomy ii)colorectal surgery iii)hepato-biliary-pancreatic(HBP) surgery 2)The age of patients >= 20 years

Exclusion criteria

Exclusion criteria: 1)Epidural catheter can not to be inserted technically 2)Platelet counts <= 100,000 3)Bleeding tendency 4)Patients who can not express their pain (can not use patient-controlled anesthesia) 5)Patients with severe comorbidity(heart failure, renal failure, psychiatric disorder and so on) 6)Transaminase(AST, ALT) >= twofold more than normal limits 7)Patients who took another oral analgesic within preoperative 8 hours 8)Pregnancy or breast-feeding women 9)Aspirin-induced asthma 10)active peptic ulcer 11)Patient with allergy to acetaminophen, opioid or local anesthesia 12)Others

Design outcomes

Primary

Measure	Time frame
The amount of patient-controlled anesthesia for breakthrough analgesia at postoperative 72 hours	—

Secondary

Measure	Time frame
VAS(visual analogue scale) adverse effect	—

Countries

Japan

Contacts

Public ContactShinya Hayami

Wakayama Medical University 2nd Department of Surgery

shin-8@wakayama-med.ac.jp073-441-0613

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026