The effect of repeated botulinum toxin A therapy combined intensive rehabilitation on lower limb spasticity in post- stroke patients.

The effect of repeated botulinum toxin A therapy combined intensive rehabilitation on lower limb spasticity in post- stroke patients. - The effect of repeated botulinum toxin A therapy and intensive rehabilitation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000033463

Enrollment

Registered

2018-07-20

Start date

2018-01-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic stroke patients

Interventions

repetitive botulinum toxin A therapy and intensive rehabilitation

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with hemiplegia following a stroke that involved upper and lower limb spasticity The MAS of ankle score2 at the cycle 6 months since the onset of stroke No prior BoNT-A injections No contraindications for BoNT-A injections The patient desired additional improvements of hemiplegia.

Exclusion criteria

Exclusion criteria: Only an upper limb for BoNT-A Can not walk themselves Taking antispasticity medications A history of BoNT-A injections A history of surgery for spasticity due to stroke Severe cognitive impairment

Design outcomes

Primary

Measure	Time frame
MAS,ROM,FMA,FRT,TUG,10MWT	—

Countries

Japan

Contacts

Public ContactTakatoshi Hara

The Jikei University School of Medicine Department of Rehabilitaion Medicine

t_hara1019@yahoo.co.jp0334331111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026