Relationship between endoscopic mucosal healing and histologic inflammation during remission maintenance phase in ulcerative colitis

Relationship between endoscopic mucosal healing and histologic inflammation during remission maintenance phase in ulcerative colitis - Relationship between endoscopic mucosal healing and histologic inflammation during remission maintenance phase in ulcerative colitis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000033452

Enrollment

166

Registered

2018-07-19

Start date

2018-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ulcerative colitis

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who had remained in clinical remission with only 5-aminosalicylic acid for at least 1 year without dose modification, who had been found to have mucosal healing by colonoscopy, and who had undergone a biopsy.

Exclusion criteria

Exclusion criteria: A case which the compliance rate is less than 80%. A case using biologics agents. A case using immunomodulators.

Design outcomes

Primary

Measure	Time frame
The primary endpoint of this study was to examine whether histological healing could be a predictor of sustained remission in ulcerative colitis patients with mucosal healing.	—

Secondary

Measure	Time frame
The second endpoint was to investigate the risk factors for relapse (age, sex, affected area, disease duration, and smoking rate).	—

Countries

Japan

Contacts

Public ContactMimari Kanazawa

Dokkyo Medical University Department of Gastroenterology

mimari77@dikkyomed.ac.jp0282872147

Outcome results