Effects of Open Bite Malocclusion on Gastric Emptying Rate

Effects of Open Bite Malocclusion on Gastric Emptying Rate - Effects of Open Bite Malocclusion on Gastric Emptying Rate

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000033444

Enrollment

Registered

2018-07-19

Start date

2019-04-22

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Open Bite

Interventions

None listed

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: healthy volunteers with normal occlusion (control group), open bite patients (malocclusion group assumed to have low masticatory efficiency)

Exclusion criteria

Exclusion criteria: Exclude individuals who have history of gastrointestinal surgery, taking medications that affect gastric emptying, suffering from acute diseases such as upper respiratory inflammation and acute gastroenteritis, excessive alcohol, smoking and pregnancy.

Design outcomes

Primary

Measure	Time frame
1) Evaluation of gastrointestinal function Evaluation of gastrointestinal function is performed by a simple and noninvasive 13 C breath test method using stable isotope by gastric emptying function test. Measurement method is performed according to the 13 C breath test method gastric emptying function inspection workshop standard proposal as much as possible. Subjects take a solid test meal containing 13 C-octanate Na Sodium to muffin and ingest a cooked solid test meal and collect expiration according to the time schedule. Breath collection is performed before ingestion, using exclusive breath collection bag at 15, 30, 45, 60, 75, 90, 105, 120, 135, 150, 165, 180, 195, 210, 225, 240 minutes after ingestion. (With a certain restraint time, it is considered to be sufficiently acceptable as compared with previous past studies related to chewing function and digestive function.) During exhalation 13 CO 2 in expiration at each measurement time point using CO 2 analyzer, Measure the existence ratio and find the difference from the previous value. As an evaluation index, Tmax (the time until 13CO2 abundance ratio in breath peaks) is analyzed as an index. 2) Subjective evaluation of chewing function, gastrointestinal function Questionnaire survey is conducted to investigate the relationship with the subjective evaluation of chewing function and gastrointestinal function. 3) H. pylori test (urea breath test) 4) Masticatory function test (pre-scale) 5) Chewing time, number of chewing tests	—

Measure

Time frame

1) Evaluation of gastrointestinal function Evaluation of gastrointestinal function is performed by a simple and noninvasive 13 C breath test method using stable isotope by gastric emptying function test. Measurement method is performed according to the 13 C breath test method gastric emptying function inspection workshop standard proposal as much as possible. Subjects take a solid test meal containing 13 C-octanate Na Sodium to muffin and ingest a cooked solid test meal and collect expiration according to the time schedule. Breath collection is performed before ingestion, using exclusive breath collection bag at 15, 30, 45, 60, 75, 90, 105, 120, 135, 150, 165, 180, 195, 210, 225, 240 minutes after ingestion. (With a certain restraint time, it is considered to be sufficiently acceptable as compared with previous past studies related to chewing function and digestive function.) During exhalation 13 CO 2 in expiration at each measurement time point using CO 2 analyzer, Measure the existence ratio and find the difference from the previous value. As an evaluation index, Tmax (the time until 13CO2 abundance ratio in breath peaks) is analyzed as an index. 2) Subjective evaluation of chewing function, gastrointestinal function Questionnaire survey is conducted to investigate the relationship with the subjective evaluation of chewing function and gastrointestinal function. 3) H. pylori test (urea breath test) 4) Masticatory function test (pre-scale) 5) Chewing time, number of chewing tests

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Countries

Japan

Contacts

Public Contacthiroko ohmori

Tokyo Medical Dental University Orthodontic Sciences

ohmori.orts@tmd.ac.jp03-5803-5529

Outcome results