Atopic mild adult asthma
Conditions
Interventions
None listed
Sponsors
Department of medicine, Kurume University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. mild asthmatics and healthy non-smoking controls 2. Non-smokers 3. Stable for at least 4wks 4. %forced vital capacity >80% predicted, %forced expiratory volume in 1 sec, >80% predicted and a ratio FEV1/FVC >0.7
Exclusion criteria
Exclusion criteria: 1. Difficulty expectoration of induced sputum 2. Presence of any other moderate and severe comorbidities 3. Current or ex-smokers 4. participants who have judged that research directors and researchers are inappropriate as research subjects 5. Nursing and pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary endpoint is to investigate the correlation frequency of IL-38 positive cells per macrophage or monocytes in induced sputum and airway inflammation, hyperresponsiveness on methacholine, and asthmatic response after allergen challenge in atopic mild adult asthmatics. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoint is investigate the correlation frequency of IL-38 positive cells per macrophage or monocytes in induced sputum and peripheral blood in atopic mild adult asthmatics. We investigate whether frequency of IL-38 positive cells per macrophage or monocytes induced sputum and peripheral blood will be able to usefulness to evaluate the pathogenesis and severity of asthma as a biomarker. | — |
Countries
Japan
Contacts
Public ContactTomotaka Kawayama
Kurume University Department of medicine
Outcome results
None listed