severe aortic stenosis
Conditions
Interventions
The intervention tested in this study is to measure FFR using a guide wire that is capable of sensing pressure following TAVR. After the pressure gradient across the aortic valve is relieved by TAVR,
Sponsors
Division of Cardiovascular Medicine, Department of Internal Medicine, Graduate School of Medicine, Kobe University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who meet all the following criteria will be included in the study: 1)Among patients who have undergone CCTA prior to TAVR, those with moderate stenotic lesions (30 to <70%) or severe stenotic lesions on CT who are candidates for PCI following TAVR 2)Patients aged 20 years or older at the time of diagnosis
Exclusion criteria
Exclusion criteria: Patients who meet any one of the following criteria will be excluded from this study: 1)Patients who were implanted with metal stents in the left main trunk, 2)Patients with stenosis of >30% in the left main trunk who were implanted with at least one metal stent in the vessel(s) of the left coronary circulation, 3)Patients who were implanted with metal stents in at least 2 vessels of the coronary circulation, 4)Patients who requested withdrawal of consent for participation in this research study after providing their consent, 5)Patients who underwent coronary artery bypass surgery, 6)Patients with coronary artery chronic total occlusion, 7)Patients who developed acute myocardial infarction in the past 2 months, 8)Patients whose CCTA was determined to be unreadable during its evaluation at the study site because of the presence of artifacts which were severe enough to cause problems with the angiogram, 9)Patients who were judged by the principal investigator to be unsuitable for the study for other reasons
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A cut-off value for FFRct that can estimate FFR of <0.80 in patients with severe AS | — |
Secondary
| Measure | Time frame |
|---|---|
| (1)A cut-off value for pre-TAVR iFR that can estimate FFR of <0.80 in patients with severe AS (2)Regression and correlation coefficient of FFRct before TAVR and after TAVR (3)Regression and correlation coefficient of iFR before TAVR and after TAVR (4)Stenosis degree in coronary angiography before TAVR predicting FFR: <0.80 in severe AS patients | — |
Countries
Japan
Contacts
Public ContactRyo Takeshige
Graduate School of Medicine, Kobe University Division of Cardiovascular Medicine, Department of Internal Medicine
Outcome results
None listed