Food allergy
Conditions
Interventions
Oral immunotherapy with a target dose of middle-dose
Oral immunotherapy with ingestion of low-dose
Sponsors
National Hospital Organization Sagamihara National Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who performed low-dose oral immunotherapy (target dose of one eight of whole egg, 3 ml of cow's milk, 2g of Udon (Japanese wheat noodles), 0.5g of whole peanut or 0.5g of nut) for 12 months or more. Patients who achieved desensitization to low-dose and have been asymptomatic for 3 months or more. Patients who failed middle-dose oral food challenge after 2 weeks of complete avoidance.
Exclusion criteria
Exclusion criteria: Decision of ineligibility by a physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sustained unresponsiveness to middle-dose after 12 months. Middle dose was defined as "half of a whole egg, 25 ml of cow's milk, 25g of Udon, 3g of peanut or 3g of nut". | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes of specific IgE, IgG, IgG4 Frequency of adverse reactions The rate of sustained unresponsiveness to middle-dose after 5 years from start of OIT. | — |
Countries
Japan
Contacts
Public ContactKen-ichi Nagakura
National Hospital Organization Sagamihara National Hospital Department of pediatrics
Outcome results
None listed