Relationship between coronary artery plaque burden and High Mobility Group Box 1 (HMGB1): prospective cohort study

Relationship between coronary artery plaque burden and High Mobility Group Box 1 (HMGB1): prospective cohort study - Coronary artery plaque and HMGB1

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000033308

Enrollment

150

Registered

2018-07-07

Start date

2018-07-06

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary artery disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Underwent elective coronary angiography or coronary intervention

Exclusion criteria

Exclusion criteria: patients with fever-up, acute and chronic infection, thyroid abnormality, collagen disease, using oral steroid therapy or using inhaled corticosteroid. a patient judged inappropriate by doctor

Design outcomes

Primary

Measure	Time frame
Comparison of HMGB1 and lipid plaque burden detected by integrated backscatter intravascular ultrasound (IB-IVUS)	—

Secondary

Measure	Time frame
i) Comparison of HMGB1 and instantaneous wave free ratio (iFR) or fractional flow reserve (FFR) in coronary angiography ii) Comparison of HMGB1 and % coronary stenosis calculated by quantitative coronary angiography (QCA) iii) Comparison of HMGB1 and slow flow phenomenon during coronary intervention iv) Comparison of HMGB1 and the grade of coronary collateral vessel v) Comparison of HMGB1 and the incidence of restenosis after coronary intervention vi) Comparison of HMGB1 and the incidence of composite endpoint of cardiac death, myocardial infarction, revascularization and stent thrombosis vii) Comparison of HMGB1 and inflammatory biomarkers of histone H3, syndical-1, lipoprotein(a) and oxidized lipoprotein(a), in addition relationship between these biomarkers and iFR, IB-IVUS and cardiovascular events viii) Comparison of HMGB1 and ankle brachial index (ABI)	—

Measure

Time frame

i) Comparison of HMGB1 and instantaneous wave free ratio (iFR) or fractional flow reserve (FFR) in coronary angiography ii) Comparison of HMGB1 and % coronary stenosis calculated by quantitative coronary angiography (QCA) iii) Comparison of HMGB1 and slow flow phenomenon during coronary intervention iv) Comparison of HMGB1 and the grade of coronary collateral vessel v) Comparison of HMGB1 and the incidence of restenosis after coronary intervention vi) Comparison of HMGB1 and the incidence of composite endpoint of cardiac death, myocardial infarction, revascularization and stent thrombosis vii) Comparison of HMGB1 and inflammatory biomarkers of histone H3, syndical-1, lipoprotein(a) and oxidized lipoprotein(a), in addition relationship between these biomarkers and iFR, IB-IVUS and cardiovascular events viii) Comparison of HMGB1 and ankle brachial index (ABI)

—

Countries

Japan

Contacts

Public ContactKoichiro Matsumura

Kansai Medical University Medical Center Department of Cardiology

kmatsumura1980@yahoo.co.jp06-6992-1001

Outcome results