Association of Lecithin-cholesterol Acyltransferase Activity and Low-density Lipoprotein Heterogeneity with Atherosclerotic Cardiovascular Risk: A Pilot Longitudinal Study

Association of Lecithin-cholesterol Acyltransferase Activity and Low-density Lipoprotein Heterogeneity with Atherosclerotic Cardiovascular Risk: A Pilot Longitudinal Study - LCAT activity and LDL-particle size

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000033228

Enrollment

400

Registered

2018-07-02

Start date

2018-07-02

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The criterion for patient registration was the presence of one or more risk factors for atherosclerosis.

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The criterion for patient registration was the presence of one or more risk factors for atherosclerosis.

Exclusion criteria

Exclusion criteria: hepatic dysfunction (alanine aminotransferase and aspartate aminotransferase more than 2 times the upper limit of the normal values), known malignant disease, refusal to provide consent for participation in the study, or the diagnosis of acute coronary syndrome within 3 months prior to the study, and/or serum TG 400 mg/dL.

Design outcomes

Primary

Measure	Time frame
The primary endo point was to evaluate the association of the absolute change in LCAT activity with the change in LDL particle size, using a multilogistic regression analysis	—

Countries

Japan

Contacts

Public ContactShigemasa Tani

Nihon University Hospital Department of Cardiology

tanishigem@yahoo.co.jp03-3293-1711

Outcome results