Anterior cruciate ligament injury
Conditions
Interventions
In patients assigned to desflurane group, following intravenous bolus injections of midazolam 1mg and remifentanil 20ug, a continuous intravenous infusion of midazolam at 0.05mg/kg/hr was maintained c
Sponsors
Medical Corporation Sakai Orthopedics Fukuoka Sports Clinic
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients who are being enforced by a medical corporation Sakai Orthopedics, Fukuoka Sports Clinic for reconstructive anterior cruciate ligament (hamstring and lamina tendon transplant) 2) 16 years old and under 50 3) Any professional or amateur 4) Cases of sports enthusiast and injuries related to competition 5) Patients who received written consent (from minors in person and from substitute)
Exclusion criteria
Exclusion criteria: 1) There has been a history of injury on the same side in the past 2) Cases with complex injuries 3) Patients who are predisposed to allergies to venous anesthetic propofol or volatile anesthetic desflurane 4) Patients contraindicated in regional anesthesia, difficult cases of puncture due to obesity or spinal deformity, patients who have difficulty in prescribing anesthesia and postoperative analgesia due to insufficient anesthetic effect 5) Cases in which a tourniquet pressure was required up to a pressure exceeding 250 mmHg
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skeletal muscle cell damage quantified by the release of postoperative creatine phosphokinase-MM (CPK-MM) and the areas under the curve of the CPK-MM concentrations over the 24 h (AUC24 h) and the 48h (AUC48 h). Blood samples are taken preoperatively and 6, 12, 24, and 48 h following release of tourniquet. | — |
Secondary
| Measure | Time frame |
|---|---|
| Skeletal muscle cell damage quantified by the release of postoperative myoglobin and the areas under the curve of the myoglobin concentrations over the 24 h (AUC24 h) and the 48h (AUC48 h). Blood samples are taken preoperatively and 6, 12, 24, and 48 h following release of tourniquet. For operative side, cross-sectional areas of quadriceps femoralis muscles were traced and calculated on MRI before operation and postoperative day 9th, at two slices of 5 cm and 10 cm above the upper margin of the patella, respectively. Change ratio of the areas at the same slice before and after operation was examined.The change ratios of patinets managed with desflurane were compared with those of patients managed with propofol at the corresponding slice, respectively. | — |
Countries
Japan
Contacts
Public ContactTadahiro Horiguchi
Medical Corporation Sakai Orthopedics Fukuoka Sports Clinic Research Bureau
Outcome results
None listed