Healthy subjects
Conditions
Interventions
Placebo
Low-dose amino acid-enriched food
Medium-dose amino acid-enriched food
Sponsors
Tokyo Metropolitan Institute of Gerontology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Subjects whose MMSE-J score is 26 or higher, and MoCA-J score less than 30. 2) Subjects who have noticeable symptoms of memory loss or whose memory loss has been pointed out by others. 3) Subjects who provided written informed consent.
Exclusion criteria
Exclusion criteria: 1) Individuals who have a history of mental or cerebrovascular diseases. 2) GDS-S-J score above 6. 3) Individuals who use medicines which may affect central nervous system except for sleeping pills. 4) Individuals who regularly intake supplements or functional foods which may affect cognitive function. 5) Individuals who have visual impairment or hearing impairment. 6) Individuals who have a history of alcohol dependence. 7) Individuals who are under medical treatment of cancer or cirrhosis of liver. 8) Dialysis patients. 9) Individuals who have allergy of milk or lactose intolerance. 10) Individuals with phenylketonuria. 11) Individuals who participate or will participate in other clinical studies. 12) Individuals who are assessed to be inappropriate by the principal investigator due to other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive function Battery | — |
Secondary
| Measure | Time frame |
|---|---|
| *Secondary outcomes SF-36, WHO-5-J, Questionnaire survey (Related to Activity, Cognitive decline, Social involvement, Care prevention, Social capital, Multidimensional Empathy Scale, VAS), Amino acids and other metabolites *Safety Adverse event, side effect, blood pressure, pulse rate, BMI, clinical test result | — |
Countries
Japan
Contacts
Public ContactYoshika Komori
KSO Corporation Executive chairman
Outcome results
None listed