The relationship between level of lugol-staining of esophageal squamous epithelium (risk for incidence of esophageal squamous cell carcinoma (ESCC)) and impaired barrier function by acetaldehyde

The relationship between level of lugol-staining of esophageal squamous epithelium (risk for incidence of esophageal squamous cell carcinoma (ESCC)) and impaired barrier function by acetaldehyde - Esophageal acetaldehyde study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000033165

Enrollment

Registered

2018-06-28

Start date

2018-06-28

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Superficial ESCC

Interventions

Measuring esophageal mucosal barrier function in ENSE in patients with ESCC, using mini-Ussing chamber system Measuring esophageal mucosal barrier function in LVL in patients with ESCC, using mini-Uss

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1)The patients with superficial ESCC who will receive endoscopic resection (2)The patients with Eastern Cooperative Oncology Group performance status of 0-1 (3)The patients with aged 20 years or more (4)The patients who agreed with informed consent

Exclusion criteria

Exclusion criteria: (1)Patients with regular use of NSAIDs, steroids, or immunosuppressive agents (2)Patients with a history or a plan of surgery for esophagus, stomach, or duodenum (3)Patients with a history of chemotherapy or radiation therapy against head and neck or esophageal cancers (4)Patients with regular use of two or more anticoagulant or antiplatelet medication (5)Patients with severe systemic diseases (6)Pregnant or breastfeeding women (7)Patients who participated in another studies with esophageal biopsies (8)Patients with severe mental disease (9)Patients who are judged inappropriate to entry the study

Design outcomes

Primary

Measure	Time frame
Esophageal mucosal barrier dysfunction in biopsy specimens of ENSC and LVL, which are exposed by acetaldehyde	—

Secondary

Measure	Time frame
1)Level of tight junction protein (TJP)/adhesion junction protein (AJP) in biopsy specimens of ENSE and LVL 2)Level of TJP/AJP RNA in biopsy specimens of ENSE and LVL 3)Oxidative stress marker, endogenous oxidase, and microRNA level in biopsy specimens of ENSE and LVL 4)The relationship between the epithelial barrier dysfunction and the amount of drinking and smoking or ALDH2/ADH1B polymorphism in biopsy specimens of ENSE and LVL	—

Measure

Time frame

1)Level of tight junction protein (TJP)/adhesion junction protein (AJP) in biopsy specimens of ENSE and LVL 2)Level of TJP/AJP RNA in biopsy specimens of ENSE and LVL 3)Oxidative stress marker, endogenous oxidase, and microRNA level in biopsy specimens of ENSE and LVL 4)The relationship between the epithelial barrier dysfunction and the amount of drinking and smoking or ALDH2/ADH1B polymorphism in biopsy specimens of ENSE and LVL

—

Countries

Japan

Contacts

Public ContactWaku Hatta

Tohoku University Graduate School of Medicine Division of Gastroenterology

waku-style@festa.ocn.ne.jp022-717-7171

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026