Impact of impaired barrier function of esophageal squamous epithelium by acetaldehyde and ethanol on carcinogenesis of esophageal squamous cell carcinoma (ESCC)

Impact of impaired barrier function of esophageal squamous epithelium by acetaldehyde and ethanol on carcinogenesis of esophageal squamous cell carcinoma (ESCC) - Esophageal acetaldehyde/ethanol study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000033164

Enrollment

Registered

2018-06-28

Start date

2018-06-28

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Superficial esophageal carcinoma

Interventions

Measuring barrier function of esophageal squamous epithelium in patients with ESCC, using mini-Ussing chamber system Measuring barrier function of esophageal squamous epithelium in patients without ES

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with ESCC (1) The patients with superficial ESCC who will receive endoscopic resection (2) The patients with Eastern Cooperative Oncology Group performance status (ECOG-PS) of 0-1 (3) The patients with aged 20 years or more (4) The Patients who agreed with informed consent Control (1) The patients with early gastric cancer who will receive endoscopic resection (2) The patients without ESCC (3) The patients with ECOG-PS of 0-1 (4) The patients whose age and gender is matched with those with ESCC (5) The patients written informed consent

Exclusion criteria

Exclusion criteria: (1) Patients with regular use of NSAIDs, steroids, or immunosuppressive agents (2) Patients with a history or a plan of surgery for esophagus, stomach, or duodenum (3) Patients with a history of chemotherapy or radiation therapy against head and neck or esophageal cancers (4) Patients with regular use of two or more anticoagulant or antiplatelet medication (5) Patients with severe systemic diseases (6) Pregnant or breastfeeding women (7) Patients who participated in another studies with esophageal biopsies (8) Patients with severe mental disease (9) Patients who are judged inappropriate to entry the study

Design outcomes

Primary

Measure	Time frame
Barrier dysfunction of esophageal squamous epithelium in biopsy specimen exposed by acetaldehyde +/- ethanol in patients with and without ESCC	—

Secondary

Measure	Time frame
1) Level of tight junction protein (TJP)/adhesion junction protein (AJP) in biopsy specimen of esophagus in patients with and without ESCC 2) Level of TJP/AJP RNA in biopsy specimen of esophagus in patients with and without ESCC 3) Oxidative stress marker, endogenous oxidase, and microRNA level in biopsy specimen of esophagus in patients with and without ESCC 4) The relationship between the barrier dysfunction of esophageal squamous epithelium and the amount of drinking and smoking or ALDH2/ADH1B polymorphism	—

Measure

Time frame

1) Level of tight junction protein (TJP)/adhesion junction protein (AJP) in biopsy specimen of esophagus in patients with and without ESCC 2) Level of TJP/AJP RNA in biopsy specimen of esophagus in patients with and without ESCC 3) Oxidative stress marker, endogenous oxidase, and microRNA level in biopsy specimen of esophagus in patients with and without ESCC 4) The relationship between the barrier dysfunction of esophageal squamous epithelium and the amount of drinking and smoking or ALDH2/ADH1B polymorphism

—

Countries

Japan

Contacts

Public ContactWaku Hatta

Tohoku University Graduate School of Medicine Division of Gastroenterology

waku-style@festa.ocn.ne.jp022-717-7171

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026