Autism Spectrum Disorder, Attention Deficit Hyperactive Disorder
Conditions
Interventions
None listed
Sponsors
Keio University School of Medicine Neuropsychiatry dpt
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: <In cases of ASD, ADHD children> (including co-existence of ASD and ADHD) Age above 6 years old and less than 13 years old at the time of agreement. <In cases of their siblings> Age above 6 years old and less than 13 years old at the time of agreement. <In cases of healthy participants> Typically developing children who are willing to participate in the study without family history of psychiatric disorders. Age above 6 years old and less than 13 years old at the time of agreement
Exclusion criteria
Exclusion criteria: <In cases of ASD, ADHD children> Having other mental disorders, organic brain abnormalities (epilepsy, schizophrenia, obsessive-compulsive disorder, etc.) Having serious systemic physical disorders (thyroid dysfunction, immune diseases, etc.) Underwent surgery due to serious gastrointestinal disorder or in treatment of severe gastrointestinal disorders(gastrointestinal cancer, congenital bowel obstruction, Hirschsprung disease etc.) Received antibiotics within 3 months Collection of fecal samples can not be performed for any reason (such as mental symptoms can be worsened due to stress, etc.) Psychological symptoms may worsen due to mental and physical burden caused by interview evaluation conducted in this research Other reasons in which researchers considered to be inappropriate <In cases of their siblings> Having serious systemic physical disorders (thyroid dysfunction, immune diseases, etc.) Having undergone surgery due to serious gastrointestinal disorder or in treatment of severe gastrointestinal disorders(gastrointestinal cancer, congenital bowel obstruction, Hirschsprung disease etc.) Received antibiotics within 3 months Collection of fecal samples can not be performed for some reason Large burden caused by interview evaluation conducted in this research Other reasons in which researchers considered to be inappropriate <In cases of healthy participants> Family history of mental illness within the second degree, Having serious systemic physical disorders (thyroid dysfunction, immune diseases, etc.) Having undergone surgery due to serious gastrointestinal disorder or in treatment of severe gastrointestinal disorders(gastrointestinal cancer, congenital bowel obstruction, Hirschsprung disease etc.) Received antibiotics within 3 months Collection of fecal samples can not be performed for some reason Large burden caused by interview evaluation conducted in this research Other reasons in which researchers considered to be inappropriate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Feces samples will be collected at least 3 times during one month period. Bacterial metagenome and metabolomics will be assessed with 16SrRNA methodology and Mass spectrometry | — |
Secondary
| Measure | Time frame |
|---|---|
| To Patients Autism Diagnostic Observation Schedule: ADOS-2 Childhood Autism Rating Scale: CARS To parents or caregivers of all children Original questionnaire of lifestyles and Growth history Brief-type self-administered Diet History Questionnaire: BDHQ Autism-spectrum quotient: AQ-J Conners 3 Abberant Behavior Checklist: ABC-J Sensory Profile: SP Gastrointestinal Symptom Rating Scale: GSRS Original questionnaire of Gastrointestinal Symptom | — |
Countries
Japan
Contacts
Public ContactTaishiro Kishimoto
Keio University School of Medicine Hills Joint Research Laboratory for Future Preventive Medicine and Wellnes
Outcome results
None listed