Esophageal cancer
Conditions
Interventions
Supplemental home enteral nutrition (at least 300 kcal / day or more) is continued up to 8 weeks after curative esophagectomy,
Supplemental home enteral nutrition (at least 300 kcal / day or more) is
Sponsors
Tohoku University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Primary lesions are all confined within the thoracic esophagus, 2) an esophageal epithelial malignancy, 3) Surgery approached from the neck, chest and abdomen, 4) R0 resection with D2 dissection, 5) Tube jejunostomy was constructed at the esophagectomy, 6) >20 and <80 y.o., 7) ECOG-PS 0 or 1, 8) No history of surgery for esophageal cancer, 9 ) No history of chemotherapy or radiotherapy, 10) a) WBC >2000 and <10000/mm3, b) PLT >50000/mm3, c) AST <100 IU/L, ALT <100IU/L, d) T-Bil <2.0 g/dl, e) Cre <1.5mg/dl, 11) Written consent
Exclusion criteria
Exclusion criteria: 1) BMI <17.0 or >30.0, 2) Excision of other organs excluding stomach or gall bladder, 3) Active double cancer, 4) Pregnancy or breast-feeding, 5) Psychosis or mental symptoms, 6) Systemic administration of steroids, 7) History of myocardial infarction or unstable angina, 8) Poorly controlled hypertension, 9) Poorly controlled diabetes, 10) Respiratory disease requiring sustained oxygen therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weight loss of more than 10% (24 weeks after surgery) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Change rate of QOL score, 2) Readmission rate, 3) Incidence of an adverse event (associated with home enteral nutrition), 4) Length of indwelling a feeding jejunostomy tube, 5) Adherence rate of protocol treatment | — |
Countries
Japan
Contacts
Public ContactHiroshi Okamoto
Tohoku University Hospital Department of Surgery
Outcome results
None listed