The effect of intravenous acetaminophen on postoperative temperature after cardiac surgery with cardiopulmonary bypass

The effect of intravenous acetaminophen on postoperative temperature after cardiac surgery with cardiopulmonary bypass - The effect of acetaminophen on postoperative temperature after cardiac surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000033064

Enrollment

Registered

2018-06-21

Start date

2023-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients after cardiac surgery

Interventions

Acetaminophen is administered intravenously every 6 hours since 30 minutes after weaning from cardiopulmonary bypass. The amount of acetaminophen is 15 mg/kg. ( maximal dose: 1000mg ) Physiological s

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients admitted to Nagasaki University Hospital to receive elective cardiac surgery with cardiopulmonary bypass

Exclusion criteria

Exclusion criteria: 1. preoperative liver dysfunction ( ALT > = 126 U/L or Child-Pugh score A, B or C) 2. preoperative renal dysfunction ( eGFR < = 30 mL/min/1.73m^2) 3. patients with allergic history against acetaminophen 4. patients with peptic ulcer 5. patients with severe hematologic disease 6. patients with history of aspirin-induced asthma 7. pregnant or breast-feeding women 8. preoperative use of steroids 9. re-operated patients 10. patients with re-induction of cardiopulmonary bypass during operation 11. patients undergoing re-operation because of postoperative hemorrhage 12. patients judged inappropriate

Design outcomes

Primary

Measure	Time frame
The highest temperature during 24 hours after ICU admission	—

Countries

Japan

Contacts

Public ContactSOJIRO MATSUMOTO

Nagasaki University Hospital Division of intensive care

s-matsumoto@nagasaki-u.ac.jp095-819-7200

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026