Acute liver damage
Conditions
Interventions
We perform asialoglycoprotein receptor imaging in patients with acute liver damage within 3 weeks and 1 to 2 months after the onset of acute liver damage. The dose of Tc-99m-GSA used for each asialogl
Sponsors
Osaka City University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Over 20 years old. 2. Asialoglycoprotein receptor imaging can be performed within 3 weeks from the onset of acute liver damage. The definition of acute liver damage is "patients showing alanine transferase values of 100 IU/L or more or total bilirubin values of 3.0 mg/dL or more due to acute liver damage, where the liver function prior to the current onset of liver damage is estimated to have been normal based on laboratory tests and imaging tests.
Exclusion criteria
Exclusion criteria: 1. Severe psychiatric disorder or psychiatric symptom is merged. (provided, however, judged by the attending physician.) 2. Asialoglycoprotein receptor imaging can not be performed due to poor general condition. 3. Long-term resting supine position is difficult due to back pain. 4. Pregnant or lactating woman. 5. In a case that the researchers judge it is difficult to carry out the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of patients in whom chief physician judge 2nd asialoglycoprotein receptor imaging to be meaningful. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Comparison of treatment policies before and after asialoglycoprotein receptor imaging, and a rate of treatment policy change. 2. Percentage of patients falling into acute liver failure. 3. Correlation between the duration until falling into acute liver failure and quantitative value of asialoglycoprotein receptor imaging and its rate of change. 4. Correlation between the duration of liver damage status and quantitative value of asialoglycoprotein receptor imaging and its rate of change. 5. Percentage of patients who develop hepatic coma above II degree. 6. Correlation between the duration until developing hepatic coma above II degree and quantitative value of asialoglycoprotein receptor imaging and its rate of change. 7. Percentage of patients who died from acute liver failure. 8. Correlation between the duration until death due to acute liver failure and quantitative value of asialoglycoprotein receptor imaging and its rate of change. | — |
Countries
Japan
Contacts
Public ContactKohei Kotani
Osaka City University Graduate School of Medicine Hepatology
Outcome results
None listed