Multicenter study for isolated proximal IgG4-relaed sclerosing cholangitis: diagnosis and prognosis

Multicenter study for isolated proximal IgG4-relaed sclerosing cholangitis: diagnosis and prognosis - isolated proximal IgG4-SC

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000033030

Enrollment

Registered

2018-06-18

Start date

2018-06-02

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

isolated proximal IgG4-SC

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Chalacteristic diffuse or segmental bile duct stricture with mucosal thickness 2.IgG4SC without autoimmune pancreatitis, nor atrophic pancreas 3.Presence of elavated serum IgG4 level over 135mg/dL 4.The presence with IgG4-related dacryoadenitis and/or IgG4-related retroperitoneal fibrosis 5.The histopathological findings; 1) marked Lymphoplasma cells infiltraion and fibrosis in the bile duct 2) IgG4-bearing plasmacells infiltration over 10cell/HPF 3) storiform fibrosis 4) obliterative phlebitis 6.steroid effectiveness Definite diagnosis; 1+2+3+4 1+2+3+6 or 5

Exclusion criteria

Exclusion criteria: IgG4-SC with autoimmune pancreatitis

Design outcomes

Primary

Measure	Time frame
diagnostic rate for isolated proximat IgG4-SC	—

Secondary

Measure	Time frame
1.cholangiography (ERC or MRCP) 2.endosonographic and/or intraductal urtrasonographic features of the bile duct 3. findings of extra-bile duct lesions	—

Countries

Japan

Contacts

Public Contacttakuya takayanagi

Yokohama City University Hospital Endoscopic devision

t_takayanagi1987@yahoo.co.jp0457872800

Outcome results