chronic kidney disease
Conditions
Interventions
1 packet of Yakult Super Synbiotics as probiotics and 6.8g of Oligosaccharide as prebiotics three times a day for four weeks. Yakult Super Synbiotics contains Lactobacillus casei strain Shirt and Bif
Sponsors
ShonanKamakura General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Patients with CKD stage 5 (eGFR <15 mL/min/1.73 m2) 2)Patients scheduled to undergo dialysis within about 3 months 3)More than 20 years old, either sex 4) Patients who are able to provide informed consent
Exclusion criteria
Exclusion criteria: 1) Patients who received antibacterial treatment by oral or intravenous administration within 1 week before the introduction of dialysis 2) Patients who ingested the study drug of this study or similar substances within 1 week before the introduction of dialysis 3) Patients who received or ingested lactic acid bacteria-containing preparations or oligosaccharide preparations manufactured by Yakult Co., Ltd. within 2 weeks before the introduction of dialysis. 4) Patients who used an intestinal regulator or an oral medical spherical adsorption charcoal within 2 weeks before the introduction of dialysis 5) Patients taking immunosuppressive agents within 6 months before the introduction of dialysis 6) Patients with acute renal failure 7) Patients who have had a kidney transplant before 8) Patients with irritable bowel syndrome, Crohn's disease, ulcerative colitis 9) Patients who have been allergic to milk 10) Pregnant or potentially pregnant women 11) Breastfeeding women 12) Patients who received another study drug or study drug within 3 months before the start of administration of the study drug
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The variation in blood concentrations of p-cresol is measured before initiation of dialysis and four weeks after initiation. Participants are randomized to symbiotic intake or no treatment. After four weeks intervention, the changes in blood P cresol values are compared. | — |
Countries
Japan
Contacts
Public ContactMasahiro Hirata
ShonanKamakura General Hospital Clinical Research Division, Support Office
Outcome results
None listed