Comparison of the minimum alveolar concentrations of desflurane and sevoflurane required for maintaining bispectral index below 50 between elderly and super-elderly patients

Comparison of the minimum alveolar concentrations of desflurane and sevoflurane required for maintaining bispectral index below 50 between elderly and super-elderly patients - Concentration of volatile anesthetics required in the elderly

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000032960

Enrollment

100

Registered

2018-06-12

Start date

2018-06-13

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diseases requiring surgical treatment

Interventions

To provide general anesthesia with predetermined concentration of desflurane to elderly (66-80 yr) patients and measure bispectral index To provide general anesthesia with predetermined concentration

= 81 yr) patients and measure bispectral index To provide general anesthesia with predetermined concentration of sevoflurane to elderly (66-80 yr) patients and measure bispectral index To provide gene

= 81 yr) patients and measure bispectral index

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with American Society of Anesthesiologists physical status I or II

Exclusion criteria

Exclusion criteria: Patients with 1) asthma, 2) arrhythmia, 3) psychiatric diseases or neuromuscular diseases 4) ischemic heart diseases or decreased cardiac function with left ventricular ejection fraction equal to or lower than 40% 5) hypotension with systolic blood pressure equal to or lower than 80 mmHg 6) Serum sodium levels equal to or lower than 135 mEq/l or equal to or higher than 148 mEq/l

Design outcomes

Primary

Measure	Time frame
Bispectral index during anesthesia with desflurane and sevoflurane	—

Countries

Japan

Contacts

Public ContactYutaka Oda

Osaka City Juso Hospital Department of Anesthesiology

yutakaodayutaka@gmail.com06-6150-8000

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026