Evaluation of the magnetic susceptibility in the brain in patients with dementia

Evaluation of the magnetic susceptibility in the brain in patients with dementia - Evaluation of the magnetic susceptibility in dementia

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000032945

Enrollment

Registered

2018-06-11

Start date

2017-09-06

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dementia

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: [Patients Group] 1) >20 and <90 years old 2) MRI examination within one month after obtaining informed consent, or susceptibility weighted images were scanned in past MRI exam. 3) informed consent is obtained after detailed explanation [Control Group] 1) sex and age matched subjects with patients group 2) informed consent is obtained

Exclusion criteria

Exclusion criteria: [Patients Group] (1)metallic implant and other MRI contraindicated objects (2)pregnant female (including possible case) (3)claustrophobia [Control Group] (1)the score of cognitive function test: MMSE<26, and MOCA-J<25 (2)abnormal MR findings or poor image quality due to motion artifact or other causes

Design outcomes

Primary

Measure	Time frame
Comparison of the local magnetic susceptibility in quantitative susceptibility mapping (QSM) between Alzheimer's patients and cognitively normal control	—

Secondary

Measure	Time frame
1) Comparison of the local magnetic susceptibility in QSM among Alzheimer's disease, dementia with Lewy bodies, frontotemporal dementia, vascular dementia, mild cognitive impairment, and others 2) Comparison of the local cerebral blood flow in arterial spin labelling (ASL) between Alzheimer's patients and control group. 3) Comparison of the local diffusion parameters in diffusion tensor image (DTI) between Alzheimer's patients and control group. 4) Comparison of the local T1 and T2* values in quantitative parametrical mapping between Alzheimer's patients and control group. 5) Correlation between the local magnetic susceptibility and other imaging parameters. 6) Correlation between local magnetic susceptibility, cognitive function test, and blood exams 7) Correlation between local magnetic susceptibility and amyloid deposition in amyloid PET	—

Measure

Time frame

1) Comparison of the local magnetic susceptibility in QSM among Alzheimer's disease, dementia with Lewy bodies, frontotemporal dementia, vascular dementia, mild cognitive impairment, and others 2) Comparison of the local cerebral blood flow in arterial spin labelling (ASL) between Alzheimer's patients and control group. 3) Comparison of the local diffusion parameters in diffusion tensor image (DTI) between Alzheimer's patients and control group. 4) Comparison of the local T1 and T2* values in quantitative parametrical mapping between Alzheimer's patients and control group. 5) Correlation between the local magnetic susceptibility and other imaging parameters. 6) Correlation between local magnetic susceptibility, cognitive function test, and blood exams 7) Correlation between local magnetic susceptibility and amyloid deposition in amyloid PET

—

Countries

Japan

Contacts

Public ContactKohsuke Kudo

Hokkaido University Hospital department of diagnostic and interventional radiology

kkudo@huhp.hokudai.ac.jp011-706-7779

Outcome results