Is there a difference in recurrence of knee pain between the Mechanical Diagnosis and Therapy and drag intervention: randomized controlled trial

Is there a difference in recurrence of knee pain between the Mechanical Diagnosis and Therapy and drag intervention: randomized controlled trial - Is there a difference in recurrence of knee pain associated with degenerative changes between the Mechanical Diagnosis and Therapy and drag intervention: randomized controlled pilot trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000032923

Enrollment

Registered

2018-06-15

Start date

2018-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee pain

Interventions

8-week intervention with Mechanical Diagnosis and Therapy etodolac x 2/day [200mg/day] for 8 weeks

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Outpatients coming to the Minami Shinjyuku Orthopedic Rehabilitation Clinic Kellgren Lawrence grade of 2-4, confirmed by an orthopaedic surgeon No contraindication for the use of etodolac Knee pain lasting for more than 1 month with the intensity of 4 or more in the 0-10 numerical rating scale

Exclusion criteria

Exclusion criteria: Symptoms or movement impairments on the lower leg originated from tissues other than the knee Communication difficulties in Japanese Outpatients for the post-surgical management History of the Around the Knee Osteotomy or the Total Knee Arthroplasty

Design outcomes

Primary

Measure	Time frame
Recruitment rate of the participants per month	—

Secondary

Measure	Time frame
Drop-out rate The number of intervention sessions of Mechanical Diagnosis and Therapy for 8 weeks (1 and 2 months after the initiation of the intervention) Exercise compliance in the mechanical Diagnosis and Therapy arm for 8 weeks Treatment stages for the derangement syndrome in Mechanical Diagnosis and Therapy arm (reduction of derangement, maintain of the reduced derangement, recovery of function, education and maintenance) (1 and 2 months after the initiation of the intervention) Flexion/extension range of motion using a goniometer (pre intervention; 1, 2, 3, 4, 5, 6, 7, 8, 11 and 14 months after the initiation of the intervention) Subjective pain in tensity (P4) (pre intervention; and 1, 2, 3, 4, 5, 6, 7, 8, 11 and 14 months after the initiation of the intervention) Quality of life (EQ5D)(pre intervention; and 1, 2, 3, 4, 5, 6, 7, 8, 11 and 14 months after the initiation of the intervention) Subjective disability (Patient Specific Functional Scale & Knee Injury and Osteoarthritis Outcome Score) (pre intervention; and 1, 2, 3, 4, 5, 6, 7, 8, 11 and 14 months after the initiation of the intervention) Treatment effect (Global Rating Recovery Scale) (1, 2, 3, 4, 5, 6, 7, 8, 11 and 14 months after the initiation of the intervention) Time for recurrence	—

Measure

Time frame

Drop-out rate The number of intervention sessions of Mechanical Diagnosis and Therapy for 8 weeks (1 and 2 months after the initiation of the intervention) Exercise compliance in the mechanical Diagnosis and Therapy arm for 8 weeks Treatment stages for the derangement syndrome in Mechanical Diagnosis and Therapy arm (reduction of derangement, maintain of the reduced derangement, recovery of function, education and maintenance) (1 and 2 months after the initiation of the intervention) Flexion/extension range of motion using a goniometer (pre intervention; 1, 2, 3, 4, 5, 6, 7, 8, 11 and 14 months after the initiation of the intervention) Subjective pain in tensity (P4) (pre intervention; and 1, 2, 3, 4, 5, 6, 7, 8, 11 and 14 months after the initiation of the intervention) Quality of life (EQ5D)(pre intervention; and 1, 2, 3, 4, 5, 6, 7, 8, 11 and 14 months after the initiation of the intervention) Subjective disability (Patient Specific Functional Scale & Knee Injury and Osteoarthritis Outcome Score) (pre intervention; and 1, 2, 3, 4, 5, 6, 7, 8, 11 and 14 months after the initiation of the intervention) Treatment effect (Global Rating Recovery Scale) (1, 2, 3, 4, 5, 6, 7, 8, 11 and 14 months after the initiation of the intervention) Time for recurrence

—

Countries

Japan

Contacts

Public ContactSanshiro Hashimoto

Minami Shinjyuku Orthopedic Rehabilitation Clinic Orthopedic

sansho@msorc.jp0353020790

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026