Colon cancer liver metastasis
Conditions
Interventions
Prescribed heavy-ion beam (carbon-ion beam) dose. Initial dose 36Gy(RBE). Dose escalated until dose limiting toxicity is met.
Sponsors
National Institutes for Quantum and Radiological Sciences and Technology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: This study included patients who: 1. has colorectal cancer liver metastasis diagnosed by radiological and clinical findings 2. with Eastern Cooperative Oncology Group performance status (ECOG PS) 0 to 2. 3. had primary colorectal lesions and lymph node metastasis removed totally by surgery (R0 resection) at least 4 weeks prior to enrollment and primary lesions to be histologically proven as CRC 4. have not received chemotherapy for at least 4 weeks prior to enrollment.
Exclusion criteria
Exclusion criteria: This study excluded patients who: 1. has evident vascular invasion. 2. had prior treatment to the specific lesion, 3. with lesions close to the intestine (less than 5 mm), 4. with uncontrollable ascites, 5. with severe liver damage, 6. with active coexisting malignancy, 7. with extra-hepatic lesions including local recurrence 8. were pregnant.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute toxicity and initial tumor response | — |
Countries
Japan
Contacts
Public ContactHirokazu Makishima
National Institutes for Quantum and Radiological Sciences and Technology National Institutes of Radiological Sciences
Outcome results
None listed