Exploratory prospective observation study of the association with preoperative plasma substance P concentration and subclinical cerebral infarction and postoperative swallowing dysfunction in patients with thoracic esophageal cancer.

Exploratory prospective observation study of the association with preoperative plasma substance P concentration and subclinical cerebral infarction and postoperative swallowing dysfunction in patients with thoracic esophageal cancer. - The association with plasma substance P concentration and subclinical cerebral infarction and aspiration

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000032896

Enrollment

150

Registered

2020-03-31

Start date

2018-06-06

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patients with histologically proved primary thoracic esophageal cancer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. histologically proved primary esophageal thoracic cancer 2. any kind of histological type 3. to undergo medical tretament 4. good general condition 5. any kind of treatment modality 6. any kind of surgical procedure in surgical case 7. gastroesophageal junctional tumor resected through right thoracotomy 8. any curativity 9. preoperative therapy does not matter. 11. 20 years or older 12. Informed consent was obtained in a document.

Exclusion criteria

Exclusion criteria: 1. neck or abdominal esophageal cancer 2. hoarseness 3. recurrent esophageal cancer 4. gastroesophageal junctional tumor resected without right thoracotomy 5. giant lymph node metastasis in the neck 6. synchronous head and neck cancer 7. past history of surgery for head and neck cancer 8. past history of irradiation for head and neck cancer 9. cormorbidity with swallowing dysfunction 10. no indication for MRI 11. claustrophobia 12. severe mental disorder 13. no current use of angiotensin-converting enzyme (ACE) inhibitors 14. judgement by attending doctor

Design outcomes

Primary

Measure	Time frame
1. The association between preoperative plasma substance P concentration and the presence or absence of subclinical cerebral infarction adjacent to the basal ganglion 2. The association between preoperative plasma substance P concentration and development of postoperative clinical aspiration	—

Secondary

Measure	Time frame
1. the association with preoperative plasma substance P concentration and preoperative swallowing function. 2. the association with location of subclinical cerebral infarction and preoperative swallowing function 3.the association with preoperative substance P concentration and postoperative swallowing function 4. the association with preoperative subclinical cerebral infarction and postoperative swallowing function 5. plasma substance P concentration at the time of developing aspiration	—

Measure

Time frame

1. the association with preoperative plasma substance P concentration and preoperative swallowing function. 2. the association with location of subclinical cerebral infarction and preoperative swallowing function 3.the association with preoperative substance P concentration and postoperative swallowing function 4. the association with preoperative subclinical cerebral infarction and postoperative swallowing function 5. plasma substance P concentration at the time of developing aspiration

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Countries

Japan

Contacts

Public ContactTakush Yasuda

Kindai University Faculty of Medicine Division of esophago-gastric surgery, Department of Surgery

takushi-yasuda6008@med.kindai.ac.jp072-288-7222

Outcome results