Depression
Conditions
Interventions
Intake probiotics for 3 months. (L. casei YIT 9029)
Sponsors
National Center of Neurology and Psychiatry
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1)Depressed patient (HAM-D score more than 11 point). (2)Subjects showing a sufficient understanding of the clinical trial procedure and agreeing to participate in the study by written informed consent at his own will. (3)For Japanese who aged 20 or over and under 65 years old when acquiring (4)Right-handed person
Exclusion criteria
Exclusion criteria: (1)Subjects who have a history of cardiovascular disease, liver disease, kidney disease, digestive tract disease and diabetes. (2)Subjects suspected to suffer from alcohol dependence and / or drug dependence. (3)Subjects who have a specific configuration that occur allergy and / or hypersensitivity against test drinks. (4)Marked suicidal ideation as indexed by three points or more on the "suicide" item of HAM-D. (5)Subjects who have edema in the brain. (6)Subjects who are diagnosed as a complication of dementia or intellectual disability. (7)Subjects who are lactating and/or pregnant. (8)Subjects who have a contraindication to MRI, such as claustrophobia, tattoo, implanted electrical device (e.g. cardiac pacemaker). (9)Those who have suffered serious head trauma or a central nervous system disease. (10)Subjects who are judged as unfit for the subject by the principal investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Hamilton Depression Rating Scale(HAM-D) 2. Mini-International Neuropsychiatric Interview 3. ROME-III/ IV 4.Distribution of bacterial in feces | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Psychometric tests 2. Plasma/Serum hormones 3. Magnetic resonance imaging | — |
Countries
Japan
Contacts
Public ContactHiroshi Kunugi
National Center of Neurology and Psychiatry Department of Mental Disorder Research
Outcome results
None listed