Efficacy of intravenous immunoglobulin replacement therapy for hypogammaglobulinemia in severe infections

Efficacy of intravenous immunoglobulin replacement therapy for hypogammaglobulinemia in severe infections - Efficacy of intravenous immunoglobulin replacement therapy for hypogammaglobulinemia in severe infections

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000032802

Enrollment

300

Registered

2018-06-01

Start date

2018-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

severe infectious diseases

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: the patients admitted to the ICU during the study period

Exclusion criteria

Exclusion criteria: 1) A case of death or survival within 24 hours after admitting to the ICU 2) Child under 15 years old

Design outcomes

Primary

Measure	Time frame
prognosis (ICU mortality rate, 28 days mortality rate, 90-days mortality rate, hospital mortality rate)	—

Secondary

Measure	Time frame
1) characteristics of the patients 2) the severity of organ failure: SOFA score JAAM-DIC score 3) Serum IgG value and IVIG dosage at admitting to the ICU 4) Evaluation of reactivity to the treatment: Changes in SOFA score, Days of vasopressors, Length of ICU days, Hospitalized Days, ventilator days	—

Countries

Japan

Contacts

Public ContactMasayuki Akatsuka

Sapporo Medical University School of Medicine Department of Intensive Care Medicine

m_a_let_go@yahoo.co.jp011-611-2111

Outcome results