Role of alpha-defensin produced by intestinal Paneth cells in heart failure

Role of alpha-defensin produced by intestinal Paneth cells in heart failure - Role of alpha-defensin produced by intestinal Paneth cells in heart failure

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000032796

Enrollment

100

Registered

2018-06-01

Start date

2020-07-29

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic heart failure

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with chronic heart failure who have a history of hospital admission or are admitted to the hospital due to congestive heart failure diagnosed by the Framingham criteria

Exclusion criteria

Exclusion criteria: 1) A patient with active inflammation 2) A patient who is taking antibiotics or has a history of taking antibiotics within the past 1 month 3) A patient with inflammatory bowel disease 4) A patient taking steroid or anti-immunosuppressant medicine 5) A patient with malignant disease whose life expectancy is less than a year 6) A patient who has a plan of hospitalization due to scheduled examination or treatment within a year 7) A patient with ventricular assist device (VAD)

Design outcomes

Primary

Measure	Time frame
Fecal and blood alpha-defensin (HD5) originated from intestinal Paneth cells	—

Secondary

Measure	Time frame
Gut microbiota, systemic inflammation, systemic oxidative stress, rates of cardiovascular events (all-cause death, heart failure-related death, all-cause hospitalization, hospitalization for worsening heart failure) etc.	—

Countries

Japan

Contacts

Public ContactTakashi Yokota

Hokkaido University Hospital Institute of Health Science Innovation for Medical Care

t-yokota@med.hokudai.ac.jp011-706-6001

Outcome results