Study of alternating chemoradiotherapy combined with proton beam therapy and intra-arterial infusion chemotherapy for advanced tongue cancer

Study of alternating chemoradiotherapy combined with proton beam therapy and intra-arterial infusion chemotherapy for advanced tongue cancer - Chemoradiotherapy combined with proton beam therapy and intra-arterial infusion chemotherapy for advanced tongue cancer

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000032732

Enrollment

Registered

2018-08-01

Start date

2009-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

locally advenced tongue cancer

Interventions

Treatment consisted of 2 courses of alternating chemoradiotherapy (radiotherapy:4 weeks) and intra-arterial infusion chemotherapy(cisplatin 20-40mg/m2) combined with 3 weeks of proton beam therapy

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)Untreated tongue cancer 2)Histologically confirmed squamous cell carcinoma 3)Stage III-IV(UICC ver.7) 4)Performance status:0-2(ECOG) 5)18-70 years old 6)WBC:>3,000/mm2, Platelet count:>100,000/mm2, Hemoglobin:>9g/dl 7)No history of radiotherapy or surgery for the head and neck region

Exclusion criteria

Exclusion criteria: 1)History of serious drug allegies 2)With severe complications(hepatic disorder, renal disorder, heart disorder, cerebral infraction)

Design outcomes

Primary

Measure	Time frame
overall survival rate	—

Secondary

Measure	Time frame
local control rate, locoregional control rate, progression free survival rate, toxicity	—

Countries

Japan

Contacts

Public ContactKanako Takayama

Southern Tohoku Proton Therapy Center department of radiation oncology

tkana-tky@umin.ac.jp024-934-3888

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026