One-week hypofractionated radiotherapy in elderly and frail patients with newly diagnosed glioblastoma

One-week hypofractionated radiotherapy in elderly and frail patients with newly diagnosed glioblastoma - One-week hypofractionated radiotherapy in elderly and frail patients with newly diagnosed glioblastoma

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000032672

Enrollment

Registered

2018-08-01

Start date

2018-08-15

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glioblastoma

Interventions

Radiotherapy (Focal 25Gy/5fraction)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Newly diagnosed and histologically confirmed glioblastoma (GBM, WHO GradeIV). 2. Registration should be completed >=7days and <=21days after resection or biopsy. The protcol treatment should start>=7days and <=28days after resection or biopsy. 3. Age >=65 years, <=75 years with performance status 3. Age >=76 years with performance status 2 or 3. 4. Regardless of use of GLIADEL Wafer 5. Patient has not received prior chemotherapy or radiotherapy. 6. Written informed consent.

Exclusion criteria

Exclusion criteria: 1. Infectious disease requiring systemic treatment. 2. Other active malignancy. 3. Dissemination. 4. Attending physician has determined unsuitable to participate in the study.

Design outcomes

Primary

Measure	Time frame
Progression free survival	—

Secondary

Measure	Time frame
Overall survival, Response rate, Adverse event, Severe adverse event, Cognitive function, Quality of life	—

Countries

Japan

Contacts

Public ContactYohei Miyake

Yokohama city university Department of Neurosurgery

ymiyaken@gmail.com045-787-2800

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026