Efficacy of oral steroids to treat the immediate symptoms of food allergy

Efficacy of oral steroids to treat the immediate symptoms of food allergy - Efficacy of steroids to treat the immediate symptoms of food allergy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000032653

Enrollment

200

Registered

2018-05-20

Start date

2018-05-20

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Food Allergy

Interventions

Taking both anti-histamines and 1 mg/kg predonisolone Taking anti-histamins

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who have undergone oral food challenge tests, and demonstrated a symptom score of 10 (skin symptom) or 11 (10 of skin symptom plus 1)according to the Anaphylaxis Scoring Aichi (ASCA).

Exclusion criteria

Exclusion criteria: Patients who have a poor physical condition, such as suffering from a cold before undergoing the oral food challenge tests. Patients who had orally taken antihistamines, leukotriene receptor antagonists, beta 2 stimulants, Th 2 cytokine inhibitors, theophylline, or oral sodium cromoglycate within 72 hours before the oral food challenge tests. Patients who received oral or intravenous steroids within 2 weeks before undergoing the oral food challenge tests. Patients that the doctor assessed as being ineligible for other reasons.

Design outcomes

Primary

Measure	Time frame
The ratio of patients who experienced a worsening the ASCA total score by 10 points or more until the end of the oral food challenge according to intention to treat analysis	—

Secondary

Measure	Time frame
The ratio of patients who experienced a worsening the ASCA total score by 10 points or more until the end of the oral food challenge according to per protocol analysis. The ratio of patients who experienced a worsening the ASCA total score by 10 points or more until the end of the oral food challenge, while excluding cases where the ASCA score deteriorated by 10 points or more before the administration of any drugs. The analysis of the efficacy of steroids was stratified according to each organ symptom. The efficacy of the steroids to suppress anaphylaxis and anaphylaxy shock. The analysis of the efficacy of steroids corrected by age, sex, past history of asthma and atopic dermatitis, antigen specific-IgE titer etc.	—

Measure

Time frame

The ratio of patients who experienced a worsening the ASCA total score by 10 points or more until the end of the oral food challenge according to per protocol analysis. The ratio of patients who experienced a worsening the ASCA total score by 10 points or more until the end of the oral food challenge, while excluding cases where the ASCA score deteriorated by 10 points or more before the administration of any drugs. The analysis of the efficacy of steroids was stratified according to each organ symptom. The efficacy of the steroids to suppress anaphylaxis and anaphylaxy shock. The analysis of the efficacy of steroids corrected by age, sex, past history of asthma and atopic dermatitis, antigen specific-IgE titer etc.

—

Countries

Japan

Contacts

Public ContactTeruaki Matsui

Aichi Children's Health and Medical Center Department of Allergy

teruaki_matsui@sk00106.achmc.pref.aichi.jp0562-43-0500

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026