The impact of Synbiotic and Prehabilitation Therapy on the postoperative outcome in patients undergoing highly invasive surgery. A randomized controlled study.

The impact of Synbiotic and Prehabilitation Therapy on the postoperative outcome in patients undergoing highly invasive surgery. A randomized controlled study. - The impact of Synbiotic and Prehabilitation Therapy on the postoperative outcome in patients undergoing highly invasive surgery.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000032635

Enrollment

160

Registered

2018-06-01

Start date

2018-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients who are going to undergo a highly invasive abdominal surgery.

Interventions

Synbiotics therapy Synbio-Prehabilitation therapy

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who are going to undergo a highly invasive surgery in Nagoya University Hospital Surgery I and II. Highly invasive surgery includes; 1. Major hepatectomy 2. Hepatopancreatoduodenectomy 3. Pancreatoduodenectomy 4. Destal pancreatectomy with celiac axis resection 5. Other highly invasive surgeries with similar invasion as above procedures

Exclusion criteria

Exclusion criteria: Patients who rejected to participate this study.

Design outcomes

Primary

Measure	Time frame
1.To compare the nutritional status, host immune function, intestinal microbitota, fecal organic acids concentrations, muscle mass, fat mass, and exercise capacity between Synbiotics group and Synbio-Prehabilitation group. 2.To Compare the incidence of postoperative complications and the length of postoperative hospital stay. 3.To investigate the correlation between the preoperative conditions including nutritional status, host immune function, intestinal microbiota, fecal organic acids concentrations, muscle mass, fat mass, and functional exercise capacity and the incidence of postoperative complications and the length of postoperative hospital stay.	—

Measure

Time frame

1.To compare the nutritional status, host immune function, intestinal microbitota, fecal organic acids concentrations, muscle mass, fat mass, and exercise capacity between Synbiotics group and Synbio-Prehabilitation group. 2.To Compare the incidence of postoperative complications and the length of postoperative hospital stay. 3.To investigate the correlation between the preoperative conditions including nutritional status, host immune function, intestinal microbiota, fecal organic acids concentrations, muscle mass, fat mass, and functional exercise capacity and the incidence of postoperative complications and the length of postoperative hospital stay.

—

Secondary

Measure	Time frame
4.To compare the long term outcome after surgery between Synbiotics and Synbio-Prehabilitation groups. 5.To investigate the impact of preoperative nutritional status, host immune function, intestinal microbiota, fecal organic acids, muscle mass, fat mass, and functional exercise capacity on the long term outcome after surgery.	—

Countries

Japan

Contacts

Public ContactYokoyama Yukihiro

Nagoya University Graduate School of Medicine Division of Surgical Oncology/Division of Gastrointestinal Surgery, Department of Surgery

yyoko@med.nagoya-u.ac.jp0527442222

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026