Multi-center, prospective study for novel biomarkers of acute liver failure in adults

Multi-center, prospective study for novel biomarkers of acute liver failure in adults - Multi-center, prospective study for novel biomarkers of acute liver failure in adults

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000032616

Enrollment

200

Registered

2018-05-16

Start date

2018-05-16

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute liver falure, Acute liver disfunction

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: ALF was diagnosed according to the criteria for ALF in Japan. In brief, patients without established chronic liver diseases and with a PT-INR of 1.5 or more caused by severe liver damage within 8 weeks of the onset of symptoms are diagnosed as having acute liver failure.

Exclusion criteria

Exclusion criteria: HCC or other malignancies; MOF before liver failure; paraproteinosis; obstructive jaundice

Design outcomes

Primary

Measure	Time frame
Non-transplant survival; transplantation; clinical outcome after liver transplantation	—

Secondary

Measure	Time frame
The dynamics of ECM remodeling, related cytokines, apoptosis or renegerative markers, coagulation factors; complications including infection or bleeding	—

Countries

Japan

Contacts

Public ContactNobuhiro Nakamoto

Keio University, School of Medicine Division of Gastroenterology and Hepatology

nobuhiro@z2.keio.jp+81-3-3353-1211

Outcome results