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The Impact of the Sampling Rate of Dynamic Myocardial Computed Tomography Perfusion on the Quantitative Assessment of Myocardial Blood Flow

The Impact of the Sampling Rate of Dynamic Myocardial Computed Tomography Perfusion on the Quantitative Assessment of Myocardial Blood Flow - Impact of Sampling Rate on CT-MBF

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000032605
Enrollment
180
Registered
2018-05-16
Start date
2016-05-10
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary artery disease

Interventions

None listed

Sponsors

Ehime University Graduate School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients who underwent stress dynamic CTP for the assessment of CAD between July 2013 and November 2017.

Exclusion criteria

Exclusion criteria: (1) acute myocardial infarction (<30 days from the onset), (2) cardiomyopathy, (3) left ventricular ejection fraction <20%, (4) atrial fibrillation, (5) an atrioventricular block greater than the first degree, (6) complete left bundle branch block, (7) history of percutaneous coronary intervention or coronary artery bypass grafting, (8) poor cardiac MR image quality, and (9) an inappropriate CTP dataset such as that with insufficient image quality, misaligned scan coverage, and delayed data acquisition of dynamic CTP causing a shorter baseline (before upslope) of the TAC in the ascending aorta.

Design outcomes

Primary

MeasureTime frame
The global CTMBFs with 2RR, 3RR, and 4RR sampling are compared with that with 1RR sampling as a reference, using the equivalence test with Bonferroni correction.

Secondary

MeasureTime frame
The Pearson rank correlation test is used to assess the relationship between the global CTMBF with 1RR sampling and that with 2RR, 3RR, or 4RR sampling. The equivalence test with Bonferroni correction is used to compare segmental CT-MBFs with 2RR, 3RR, and 4RR sampling to that with 1RR sampling for normal and abnormal myocardial segments that were assessed with cardiac MR. The areas under the receiver operating characteristic curve of segmental CT-MBF with 2RR, 3RR, and 4RR sampling are compared with that with 1RR sampling.

Countries

Japan

Contacts

Public ContactTakahiro Yokoi

Ehime University Graduate School of Medicine Radiology

mr.taka451@gmail.com+81-89-960-5371

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026