liver cirrhosis
Conditions
Interventions
Rifaximin 400 mg administered three times a day for 4 weeks.
Sponsors
Nara Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The subjects are patients with decompensated cirrhosis due to several causes, aged 18 years or older, who have been diagnosed by clinical, biochemical, and ultrasound findings.
Exclusion criteria
Exclusion criteria: The exclusion criteria are cardiac and/or respiratory failure or invasive cancer within the past 5 years; renal failure; clinical or biochemical signs of infection 28 d prior to inclusion; concomitant inflammatory bowel diseases and/or irritable bowel syndrome; previous history of gastrectomy, enterectomy, and/or liver transplantation; and developed portosystemic shunt. Patients who consume nonabsorbable disaccharides, probiotics, prebiotics, synbiotics, or other antibiotics 28 days prior to inclusion are also excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effectiveness to hepatic encephalopathy (serum ammonia value, endotoxin activity) | — |
Countries
Japan
Contacts
Public ContactKosuke Kaji
Nara Medical University Third Department of Internal Medicine
Outcome results
None listed