Clinical study of mixture of nobiletin and tangeretin in patients with nocturia

Clinical study of mixture of nobiletin and tangeretin in patients with nocturia - NOT-Nocturia study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000032536

Enrollment

Registered

2018-05-10

Start date

2018-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

nocturia

Interventions

Mixture 50mg of nobiletin and tangeretin will be orally administered every day, once after dinner for 6 weeks. After a washout period of 2 weeks, the placebo will be orally administered every day, onc

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)Patients who has to wake at night more than twice for voiding 2)Patients who has a proper comprehension and compliance 3)50 years old or more patients 4)Patients with ECOG PS 0-2 5)Patients who go to a hospital regularly

Exclusion criteria

Exclusion criteria: 1)Patients with polyuria 2)Residual urine volume is more than 200mL 3)Patients with benign prostatic hyperplasia, over active bladder and neurogenic bladder, who need the treatment other than nocturia 4)Any other patients who are regarded as unsuitable for this study by the investigator

Design outcomes

Primary

Measure	Time frame
The change of nocturnal functional bladder capacity	—

Countries

Japan

Contacts

Public ContactHaruki Ito

National Hospital Organization Kyoto Medical Center Urology

haruki@aqua.ocn.ne.jp075-641-9161

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026