A Randomized, Double-Blind Comparison Study of Royal Jelly to Improve Vascular Endothelial Function in Healthy Volunteers

A Randomized, Double-Blind Comparison Study of Royal Jelly to Improve Vascular Endothelial Function in Healthy Volunteers - The effects of royal jelly on vascular endothelial function

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000032482

Enrollment

100

Registered

2018-06-01

Start date

2018-08-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy volunteer

Interventions

Administration of capsuled royal jelly 690 mg daily (equivalent 2040 mg of fresh royal jelly) for 4 weeks. Administration of placebo supplement for 4 weeks.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Subjects who did not meet following criteria were enrolled based on the results of medical interview; 1) subjects who have been diagnosed with diabetes, hypertension, or dyslipidemia in a previous physical examination or a health consultation 2) Patients undergoing treatment for diabetes, hypertension, and dyslipidemia 3) current smokers or those who have smoked within 1 year. 4) Participates who are confirmed their willingness to participate in this study and be obtained written consent afterexplanation of the study.

Exclusion criteria

Exclusion criteria: 1) subjects who have been diagnosed with diabetes, hypertension, or dyslipidemia in a previous physical examination or a health consultation 2) current smokers or those who have smoked within 1 year. 3) Patients undergoing treatment for diabetes, hypertension, and dyslipidemia 4)patients with renal disease, gastrointestinal disease, heart disease, lung disease, neurological disease, endocrine disease, collagen disease, blood disease under medical treatment, or receiving any regular medications 5)receiving any regular medications 6)patients with serious complications, such as malignancy, or poor life expectancy 7)pregnant or potentially pregnant women 8) allergic to honey.

Design outcomes

Primary

Measure	Time frame
Improvement of vascular endothelial function assessed by the change of rective hyperemia peripheral arterial tonometry (RH-PAT) index 4 weeks after administration of royal jelly supplements.	—

Secondary

Measure	Time frame
Secondary endpoints are the change of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and gamma-glutamyl transpeptidase (gammaGT) for liver function and high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and triglycerides.	—

Countries

Japan

Contacts

Public ContactKoichiro Fujisue

Kumamoto University Hospital Cardiovascular medicine

fujisues@kumamoto-u.ac.jp81-96-373-5175

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026