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Effect Of 1% Alendronate Gel as a Local Host Modulating Agent on IL-6 Levels in GCF in Non-Surgical Management of Chronic Periodontitis - A Clinical Trial & An Immunological Analysis

Effect Of 1% Alendronate Gel as a Local Host Modulating Agent on IL-6 Levels in GCF in Non-Surgical Management of Chronic Periodontitis - A Clinical Trial & An Immunological Analysis - 1% Alendronate Gel in Chronic Periodontitis

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000032428
Enrollment
10
Registered
2018-04-30
Start date
2016-09-21
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Generalized Chronic Periodontitis

Interventions

1% Alendronate Gel

Sponsors

ITS Dental College, Hospital and Research Centre, 47, Knowledge Park III, I.T.S. Dental College, Hospital and research Centre
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Chronic Periodontitis patients as per AAP classification of 1999 with PD 5mm to 7 mm. Radiographic evidence of horizontal bone loss. No history of periodontal therapy 6 months prior to the study. No usage of antibiotics in the preceding 6 months of the study.

Exclusion criteria

Exclusion criteria: Allergy to ALN/Bisphosphonate group of drugs. Systemic ALN/Bisphosphonate group of drugs therapy. Patients suffering from Aggressive Periodontitis. Smokers and tobacco chewers. Alcoholics. Immunocompromised patients. Pregnant or lactating females. Radiographic evidence of vertical bone loss. Patient suffering from any inflammatory bone disease

Design outcomes

Primary

MeasureTime frame
In the present study the results showed statistically significant reduction in pocket probing depths (P < 0.001) and relative attachment gain (P < 0.001) at treated sites from baseline to 6 months. Similarly, there was a statistical significant reduction in IL-6 level in GCF at the treated site (P < 0.001).—

Countries

Asia(except Japan)

Contacts

Public ContactShradha Shradha

ITS Dental College, Hospital and Research Centre Department of Periodontics

sinhashraddha30@gmail.com9540846621

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026