Effects of branched-chain amino acids supplementation on skeletal muscle mass and glucose and lipid metabolism in elderly patients with type 2 diabetes: a randomized controlled study

Effects of branched-chain amino acids supplementation on skeletal muscle mass and glucose and lipid metabolism in elderly patients with type 2 diabetes: a randomized controlled study - BCAA supplementation in elderly patients with type 2 diabetes

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000032368

Enrollment

Registered

2018-06-01

Start date

2018-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes mellitus

Interventions

BCAA 6g Soy protein 7.5g

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients with type 2 diabetes. 2. Changes in HbA1c levels over the past six months are less than 1 %.

Exclusion criteria

Exclusion criteria: 1. Patients with diabetes caused by other than type 2 diabetes 2. Insulin treated patients 3. Patients with eGFR <30 ml/min/1.73m2 4. Patients with active preproliferative or proliferative diabetic retinopathy 5. Patients who do not indicate for exercise therapy due to bone and joint disease 6. Patients treated with glucocorticoids or anabolic steroids 7. Patients treated with growth hormone

Design outcomes

Primary

Measure	Time frame
Changes in skeletal muscle mass after 24-week intervention	—

Secondary

Measure	Time frame
Changes in HbA1c levels, fasting plasma glucose, HOMA-IR, serum levels of total cholesterol, triglycerides, LDL cholesterol and HDL cholesterol, amino acid profiles, tryptophan metabolites, body weight, lean body mass, fat mass, muscle strength (leg extension), grip strength, standing balance ability (index of postural stability, one-leg standing time) and score of Quick Inventory of Depressive Symptomatology	—

Measure

Time frame

Changes in HbA1c levels, fasting plasma glucose, HOMA-IR, serum levels of total cholesterol, triglycerides, LDL cholesterol and HDL cholesterol, amino acid profiles, tryptophan metabolites, body weight, lean body mass, fat mass, muscle strength (leg extension), grip strength, standing balance ability (index of postural stability, one-leg standing time) and score of Quick Inventory of Depressive Symptomatology

—

Countries

Japan

Contacts

Public ContactHiroaki Suzuki

Faculty of Medicine, University of Tsukuba Department of Internal Medicine (Endocrinology and Metabolism)

hirosuzu@md.tsukuba.ac.jp029-853-3053

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026