Treatment Resistant Depression
Conditions
Interventions
Esketamine
Racemic ketamine
Sponsors
HUPES - Hospital Universitario Professor Edgard Santos
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: All volunteers enrolled in the study must comply with all of the following at the time of the randomization: -Have the diagnosis of MDD confirmed by the Brazilian version of the Mini International Neuropsychiatric Interview 5.0.0 (MINI-Plus) (Amorim, 2000) applied by experienced and properly trained evaluators. -Be diagnosed with TRD, characterized by therapeutic failure after at least one adequate antidepressant treatment for at least 12 weeks. -Be 18 years or older
Exclusion criteria
Exclusion criteria: -Patients who have been submitted to ECT -Diagnosis of a psychotic disorder -Mental retardation or dementia (except for patients with such diagnoses who have a family member or a responsible person who may sign their informed consent form) -Decompensated heart disease -Illicit drug users.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome will be the difference in remission rates of depressive symptoms between the two treatment arms at 24 and 72 hours. Remission is defined as a MADRS score of 7 or less. | — |
Countries
South America
Contacts
Public ContactFernanda Santana Correia de Melo
Universidade Federal da Bahia Department of Psychiatry
Outcome results
None listed