The differecnces between SGLT2 and DPP4 inhibitors in blood glucose management and cardiac sympathetic nerve activity

The differecnces between SGLT2 and DPP4 inhibitors in blood glucose management and cardiac sympathetic nerve activity - The differences between SGLT2 and DPP4 inhibitors in cardiac sympathetic nerve activity

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000032277

Enrollment

Registered

2018-04-20

Start date

2017-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes mellitus (DM) patients complicated with heart failure (HF)

Interventions

If blood glucose management with patients who were administrated with DPP4 inhibitor were more bad, strict diet exercise therapy is performed and we add the dosage of DPP4 inhibitor. This therapy wi

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Out patients with DM and HF of NHYA classification of I - III who are administrated with sitagliptin. The dosage of sitagliptin does not change for 4 weeks or more. Bloo d glucose management were worsening and patients who need to strict diet/exercise therapy or change medication.

Exclusion criteria

Exclusion criteria: Pregnancy, breast-feeding, patients who may be pregnant, and patients who want pregnancy during the study Patients who may be thought to worse blood glucose management with the protocol of this study Patients with moderate or severe renal impairment (less than eGFR45) Patients with severe hepatic impairment (Child-Pugh classification C) Patients who were judged inappropriate as subjects of this study by investigators

Design outcomes

Primary

Measure	Time frame
blood glucose management	—

Secondary

Measure	Time frame
cardiac sympathetic nerve activity	—

Countries

Japan

Contacts

Public ContactShunsuke Kiuchi

Toho University Omori Medical Center Department of Cardiovascular Medicine

syunnsuke@med.toho-u.ac.jp03-3762-4151

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026