Exploratory study on the usefulness of functional MRI and Ophthalmic ultrasound to the diagnosis and prognostic prediction of prolonged consciousness disturbance

Exploratory study on the usefulness of functional MRI and Ophthalmic ultrasound to the diagnosis and prognostic prediction of prolonged consciousness disturbance - Exploratory study on the usefulness of functional MRI and Ophthalmic ultrasound to the diagnosis and prognostic prediction of prolonged consciousness disturbance

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000032120

Enrollment

Registered

2018-05-01

Start date

2018-05-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patient diagnosed as impaired consciousness that prolonged 48 hours or more after entering intensive care unit (ICU)

Interventions

Neural image evaluation after 72 hours (whole brain activation fMRI, resting f MRI, diffusion weighted imaging method, three dimensional high definition anatomical imaging, cerebral reflux MRI) and op

optic nerve sheath diameter

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patient who has consciousness disorder that prolongs more than 48 hours after entering ICU 2) Patients aged 20 years or older at the time of acquiring consent (regardless of gender) 3) After receiving sufficient explanation for the participation of this study, patients who obtained written agreement from the patient himself or a substitute

Exclusion criteria

Exclusion criteria: 1) Patients who can not image MRI 2) Patients with traumatic brain injury 3) Patients during sedation drug administration 4) Women who may be pregnant or have a possibility of pregnancy 5) Women who are breastfeeding 6) In addition, patients who are deemed inappropriate as research subjects by research managers

Design outcomes

Primary

Measure	Time frame
Neurological function as of 28th (CRS-R, GOS-E scoring value)	—

Countries

Japan

Contacts

Public ContactTakashi Ota

Shonan Kamakura General Hospital Anesthesiology

otacchi@gmail.com0467-46-1717

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026