Inflammatory Bowel Disease (IBD) and Oral Infectious Disease
Conditions
Interventions
IBD Volunteers will receive improved disinfection treatment and advice (including mechanical tooth surface and periodontal pocket cleaning) and then will follow improved home care with a super-oxidize
Sponsors
Tsurumi University School of Dental Medicine
Institute of Science Tokyo
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1 Volunteers not having severe caries and periodontal disease. 2 Volunteers not having history of any kind of gastrointestinal surgery. 3 Volunteers currently not receiving treatment of any chronic disease; however, volunteers who are taking medicinal treatment for stabilizing remission condition can take part. 4 Volunteers have not received/ receiving any kind of fecal (microbiota) transplantation. 5 Volunteers have not taken any antibiotics 3 months prior to the start of the study. 6 Volunteers who are not participating in other clinical study. 7 Volunteers who agree to participate willingly.
Exclusion criteria
Exclusion criteria: 1 Volunteers having a habit of smoking. 2 Volunteers who are pregnant or may get pregnant. 3 IBD Volunteers who will have an altered dose of medicine or receive new medicine in 3 months before that the start of the study. 4 Volunteers have taken any antibiotics 3 months prior to the start of the study. 5 Volunteers have received/ receiving any kind of fecal (microbiota) transplantation. 6 Volunteers need treatment for any other disease as priority. 7 Volunteers taking part in any other clinical study not relating to this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Qualitative and quantitative changes of oral pathogens in intestinal flora. | — |
Secondary
| Measure | Time frame |
|---|---|
| Qualitative and quantitative changes of oral pathogens in the oral cavity with an improvement of periodontal pocket depths, bleeding on probing; BOP, salivary secretion rate, hematological indices (general and specific, e.g.; albumin, CRP, hemoglobin levels), salivary calprotectin, fecal calprotectin. | — |
Countries
Japan
Contacts
Public ContactRyoko Otsuka
Tsurumi University School of Dental Medicine
Outcome results
None listed