Infective endocarditis
Conditions
Interventions
Intervention: Ampicillin/cloxacillin 4 g q4h div maximum for 6 weeks + gentamicin 3 mg/kg q24h div maximum for 2 weeks
Control: Ceftriaxone 2 g q24h div maximum for 6 weeks + gentamicin 3 mg/kg q24
Sponsors
Juntendo University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with confirmed or suspected diagnosis of infective endocarditis based on the modified Duke's criteria, who need to start empirical treatment waiting for the result of blood cultures.
Exclusion criteria
Exclusion criteria: Causative microorganism already confirmed, history of allergy or contraindication of penicillin, cepharosporins and aminoglycosides, history of prosthetic valve replacement within 1 year, eGFR less than 50 mL/min, WBC less than 1,000/microL, when physicians in charge chose another treatment regimens
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Outcome of infective endocarditis at the end of antimicrobial treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Days for defervescence less than 37 degrees Celsius, days of hospitalization, outcome at discharge, necessity of surgery during hospitalization, outcome of infective endocarditis 3 months after the end of antimicrobial treatment Adverse events on skin, blood, liver and kidney | — |
Countries
Japan
Contacts
Public ContactYuki Uehara
Juntendo University Faculty of Medicine Department of General Medicine
Outcome results
None listed