heart failure, insomnia
Conditions
Interventions
Administer Suvorexant (orexin receptor antagonist) for four days. Patients less than 65 years old will be administered a single 20 mg oral dose of suvorexant and patients over 65 years old will be adm
Sponsors
Juntendo University Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Patients admitted due to care of heart failure and diagnosed insomnia and 2)Patients who gave written informed consent
Exclusion criteria
Exclusion criteria: 1)Patients being dialysis 2)Patients can not take medicine orally 3)Patients using incompatible medicine which cause a major interaction with suvorexant. 4)Past organic cerebral disease 5)Severe liver dysfuncton 6)Patients applied inapropriate by responsible person 7)Patients have shock vital 8)Patietns using alpha blocker or nitrate medicine 9)Patients using oxygen therapy 10)Patients using CPAP therapy 11)Paitnets with pacemaker rhythm 12)Narcolepsy, Parasomnia or Sleep-related hypoventilation disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Apnea Hypopnea Index | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiac Output, Stroke volume, Blood pressure, Total peripheral resistance, Heart rate | — |
Countries
Japan
Contacts
Public ContactJun Shitara
Juntendo Hospital, Juntendo University School of Medicine Cardiovascular Medicine
Outcome results
None listed