The clarification of the immunosuppression mechanism of propofol, desflurane, and sevoflurane during lung cancer surgery and its effect on patients' outcome.

The clarification of the immunosuppression mechanism of propofol, desflurane, and sevoflurane during lung cancer surgery and its effect on patients' outcome. - The immunosuppression mechanism of intraoperative anesthetics during lung cancer surgery and its effect on the outcome.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000031911

Enrollment

100

Registered

2018-04-15

Start date

2018-05-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lung cancer

Interventions

Lung cancer patients who are enrolled the study are divided into the three group ,propofol, sevoflurane, and desflurane, as follow as randomized rule. 1 propofol group Lung cancer patients who are enr

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The patient should be over 20 years old at agreement of research is obtained. 2 the Surgery is of one side. 3 A patient with primary and metastatic lung cancer 4 patient should paerticipate who agreed document consent by free will of the research subject after having sufficient explanation for participation in this research.

Exclusion criteria

Exclusion criteria: 1 Patients taking immunosuppressants and steroids 2 Patients already had undergone chemoradiotherapy 3 Patients who is going to undergo lung surgery on both sides at the same time. 4 Patients with autoimmune diseases such as collagen disease 5 Patients who had been judged by the research director as inappropriate as the research subject .

Design outcomes

Primary

Measure	Time frame
1 The ratio of neutrophils, monocytes, and lymphocytes in the peripheral blood leukocyte 2 Evaluation of CD4/CD8 ratio, naive memory cell ratio, T cell exhaustion status. 3 Percentage of postoperative complications and recurrence 4 Duration of hospitalization, the mortality. The above items are analyzed from the blood samples at the 6 points, which includes preoperative, intraoperative (beginning and end of surgery), postoperative (1,3,5 POD), and are compared among three anesthetics groups.	—

Measure

Time frame

1 The ratio of neutrophils, monocytes, and lymphocytes in the peripheral blood leukocyte 2 Evaluation of CD4/CD8 ratio, naive memory cell ratio, T cell exhaustion status. 3 Percentage of postoperative complications and recurrence 4 Duration of hospitalization, the mortality. The above items are analyzed from the blood samples at the 6 points, which includes preoperative, intraoperative (beginning and end of surgery), postoperative (1,3,5 POD), and are compared among three anesthetics groups.

—

Countries

Japan

Contacts

Public ContactIzumi Kawagoe

Juntendo University Department of Anesthesiology and Pain clinic

ikawago@juntendo.ac.jp0338133111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026

The clarification of the immunosuppression mechanism of propofol, desflurane, and sevoflurane during lung cancer surgery and its effect on patients&#39; outcome.